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Peer-Reviewed Studies on Sexuality Since 1990
(in reverse chronological order)

INDEX
Study
Position
Researchers
Study
Position
Researchers
1. Siblings Pro Bogaert 8. Gene Switches Pro Kitamoto
2. Odors / Smell (Female) Neutral Savic-Berglund 9. Conversion Con Nicolosi et al.
3. Fruitfly Genes Pro Demir & Dickson 10. Penis Size Pro Bogaert
4. Odors / Smell (Male) Neutral Savic-Berglund 11. Inner Ear Pro McFadden
5. Eyeblink Pro Rahman 12. X-Chromosome Pro Hamer
6. Changing Orientation Con Spitzer 13. Twins Pro Bailey & Pillard
7. Lesbian Cyst Pro Agrawal 14. Hypothalamus Pro LeVay

DATE / PLACE PUBLISHED DESCRIPTION Pro, Neutral, or Con
1.
2006: June 28

Proceedings of the National Academy of Sciences

Anthony Bogaert, Ph.D., published an article on June 28, 2006, in Proceedings of the National Academy of Sciences:

"Only biological older brothers (reared with or not) and no other sibling characteristic, including nonbiological older brothers and the time reared with older biological or older nonbiological brothers, predicted men's sexual orientation. ...

These results support a prenatal origin to sexual orientation development in men...

A mother's body may have a memory for male (but not female) fetuses because she herself is female, and thus, her immune system may interpret and remember male ... fetuses as foreign. ...

...[T]he link between the mother's immune reaction and the child's future sexual orientation would probably be some effect of maternal anti-male antibodies on the sexual differentiation of the brain."
06/28/06 Anthony Bogaert

Pro
2.
2006: May 8

Proceedings of the National Academy of Sciences
(Vol. 84, No. 1, pp. 35-42)

Ivanka Savic-Berglund, M.D., Ph.D. in an interview with New Scientist about her research team's May 8, 2006 paper "Brain Response To Putative Pheromones in Lesbian Women" published in the journal Proceedings of the National Academy of Sciences, stated:

"Our study can't answer questions of cause and effect. We can't say whether the differences are because of pre-existing differences in their brains, or if past sexual experiences have conditioned their brains to respond differently."
5/8/2006 Ivanka Savic-Berglund

New Scientist published an article on May 8, 2006 about Dr. Savic's findings:

"Lesbian and heterosexual women respond differently to specific human odours, a brain-scanning study has found. The homosexual women showed similar brain activity to heterosexual men when they inhaled certain chemicals, which may be pheromones, the researchers say.

When the heterosexual women smelled AND [a chemical produced by males] their brains showed activity in the anterior hypothalamus, a region of the brain thought to process sexual cues. But EST [a chemical produced by females] only produced activity in the olfactory region of their brains, the area that processes smells. The lesbians, however, only showed activity in the olfactory region whichever odour they smelled."
5/8/2006 New Scientist

Neutral
3.
2005: June 3

Cell
(Vol. 121, pp. 785-794)

Researchers Ebu Demir and Barry J. Dickson, Ph.D. of the Institute of Molecular Biotechnology of the Austrian Academy of Sciences, in their 6/3/05 article in the journal Cell, "Fruitless Splicing Specifies Male Courtship Behavior in Drosophila," (Vol. 121, pp. 785-794) (see full article in PDF) stated:

"We show that male [gene] splicing is essential for male courtship behavior and sexual orientation. More importantly, male [gene] splicing is also sufficient to generate male behavior in otherwise normal females. These females direct their courtship toward other females (or males engineered to produce female pheromones).

The splicing of a single neuronal gene thus specifies essentially all aspects of a complex innate behavior."
6/3/05 Ebru Demir , Barry Dickson

Pro
4.
2005: May

Proceedings of the National Academy of Sciences
(Vol. 102, No. 19)

Ivanka Savic-Berglund, M.D., Ph.D. et al., in their May 2005 article in the journal Proceedings of the National Academy of Sciences "Brain Response To Putative Pheromones In Homosexual Men," (Vol. 102, No. 19) stated:

"These findings show that our brain reacts differently to the two putative pheromones compared with common odors, and suggest a link between sexual orientation and hypothalamic neuronal processes."
5/05 Ivanka Savic-Berglund

A 5/10/05 article in the New York Times, "For Gay Men, an Attraction to a Different Kind of Scent," by Nicholas Wade, stated:

"Using a brain imaging technique, Swedish researchers have shown that homosexual and heterosexual men respond differently to two odors that may be involved in sexual arousal, and that the gay men respond in the same way as women. The new research may open the way to studying human pheromones, as well as the biological basis of sexual preference. Pheromones, chemicals emitted by one individual to evoke some behavior in another of the same species, are known to govern sexual activity in animals, but experts differ as to what role, if any, they play in making humans sexually attractive to one another."
5/10/05 New York Times

Neutral
5.

2003: October

Behavioral Neuroscience
(Vol. 117, No. 5,
pp. 1096-1102)

Qazi Rahman, Ph.D. et. al., in their October 2003 article in the journal Behavioral Neuroscience (Vol. 117, No. 5, pp. 1096-1102) stated:

"The present study examined the eyeblink startle responses to acoustic stimuli of 59 healthy heterosexual and homosexual men and women. Homosexual women showed significantly masculinized PPI compared with heterosexual women, whereas no difference was observed in PPI between homosexual and heterosexual men. These data provide the first evidence for within-gender differences in basic sensorimotor gating mechanisms and implicate the known neural substrates of PPI in human sexual orientation."
10/03 Qazi Rahman

Lead researcher Qazi Rahman, Ph.D. said in a 2003 press release:

"Because the startle response is known to be involuntary rather than learned, this strongly indicates that sexual orientation is largely determined before birth."
10/03 Qazi Rahman, Ph.D.

Pro
6.

2003: October

Archives of Sexual Behavior
(Vol. 32, No. 5, pp. 403-417)

Robert L. Spitzer, M.D. et. al., in their October 2003 article in the journal Archives of Sexual Behavior (Vol. 32, No. 5, pp. 403-417) stated:

 "This study tested the hypothesis that some individuals whose sexual orientation is predominantly homosexual can, with some form of reparative therapy, become predominantly heterosexual...

The majority of participants gave reports of change from a predominantly or exclusively homosexual orientation before therapy to a predominantly or exclusively heterosexual orientation in the past year. Reports of complete change were uncommon. Female participants reported significantly more change than did male participants...

Thus, there is evidence that change in sexual orientation following some form of reparative therapy does occur in some gay men and lesbians."
10/03 Robert Spitzer

Con
7.

2003: June 30

Presented at the annual conference of the European Society of Human Reproduction and Embryology, Madrid, Spain

Rina Agrawal, M.D., Ph.D., et al., in their June 30, 2003 presentation at the annual conference of the European Society of Human Reproduction and Embryology, stated:

"Preliminary research suggests that 'Lesbians are more than twice as likely to suffer from a hormone-related condition [polycystic ovary syndrome], fueling theories that hormones play a role in developing their sexuality.'

...while there was no evidence that polycystic ovaries could be implicated as a cause of lesbianism, it was possible that this hormone imbalance could be linked to both the medical condition and sexuality."
6/30/03 Rina Agrawal

Pro
8.

2002: Sept. 16

Proceedings of the National Academy of Sciences
Vol. 99, No. 20,
pp. 13232-13237

Toshihiro Kitamoto, Ph.D., et al., in their Sept. 16, 2002 article in Proceedings of the National Academy of Sciences, stated:

"Scientists say they have found a way to 'switch' homosexual behavior on and off in male fruit flies.

The researchers were able to do this by temporarily disrupting synaptic transmissions in the flies.

Previous research indicated that the sexual orientation of fruit flies is genetically determined, but the brain pathways for controlling sexual preference weren't clear."
9/16/02  Toshihiro Kitamoto

Pro
9.

2000: June 16

Psychological Reports
Vol. 86, No. 3, Pt. 2, pp. 1071-1088

Joseph Nicolosi, Ph.D., et al., in a 2000 Psychological Reports study, stated:

"We present the results of a survey of 882 dissatisfied homosexual people whom we queried about their beliefs regarding conversion therapy and the possibility of change in sexual orientation...

Of the 882 participants, 726 of them reported that they had received conversion therapy from a professional therapist or a pastoral counselor...

Before treatment or change, only 2.2% of the participants perceived themselves as exclusively or almost entirely heterosexual, whereas after treatment or change, 34.3% perceived themselves as exclusively or almost entirely heterosexual...

As a group, the participants reported large and statistically significant reductions in the frequency of their homosexual thoughts and fantasies that they attributed to conversion therapy or self-help. They also reported large improvements in their psychological, interpersonal, and spiritual well-being."
2000 Joseph Nicolosi

Con
10.

1999: June

Archives of Sexual Behavior
Vol. 28, No. 3, pp. 213-221

Anthony Bogaert, Ph.D., in a 1999 Archives of Sexual Behavior article, "The Relation Between Sexual Orienation and Penile Size," stated:

"The relation between sexual orientation and penile dimensions in a large sample of men was studied...

Penile dimensions were assessed using five measures of penile length and circumference from Kinsey's original protocol. On all five measures, homosexual men reported larger penises than did heterosexual men.

Alterations of typical levels of prenatal hormones in homosexual men may account for these findings."
1999 Anthony Bogaert

Pro
11.

1998: March

Proceedings of the National Academy of Sciences
Vol. 95, No. 5,
pp. 2709-2713

Dennis McFadden, Ph.D. et al., in their March 1998 article in Proceedings of the National Academy of Sciences, stated:

"Researchers say they have found the first strong evidence of a physical difference between lesbians and straight women -- a finding that the inner ears of gay women work more like those of men.

The discovery adds new support to the theory that sexual orientation may be predisposed at birth."
3/98 Dennis McFadden  

Pro
12.

1993: July

Science
Vol. 261, No. 5119, pp. 291-292

Dean H. Hamer, Ph.D., et. al, in their July 1993 article in Science (Vol. 261, No. 5119, pp. 291-292) stated:

"DNA linkage analysis of a selected group of 40 families in which there were two gay brothers and no indication of nonmaternal transmission revealed a correlation between homosexual orientation and the inheritance of polymorphic markers on the X chromosome in approximately 64 percent of the sib-pairs tested.

The linkage to markers on Xq28, the subtelomeric region of the long arm of the sex chromosome, had a multipoint lod score of 4.0 (P = 10(-5), indicating a statistical confidence level of more than 99 percent that at least one subtype of male sexual orientation is genetically influenced."
7/93 Dean Hamer 

Pro
13.

1991: December

Archives of General Psychiatry
Vol. 48, No. 12,
pp. 1089-1096

J. Michael Bailey, Ph.D., and Richard C. Pillard et al., in their December 1991 article in Archives of General Psychiatry (Vol. 48, No. 12, pp. 1089-1096) stated:

"Of the relatives whose sexual orientation could be rated, 52% of monozygotic cotwins, 22% of dizygotic cotwins, and 11% of adoptive brothers were homosexual. Heritabilities were substantial under a wide range of assumptions about the population base rate of homosexuality and ascertainment bias."
12/91 J. Michael Bailey, Ph.D. , Richard Pillard, M.D.

Pro
14.

1991: June

Science,
Vol. 253,
pp. 1034-1037

Simon LeVay, Ph.D., et al., in their June 1991 article "A Difference in Hypothalamic Structure Between Heterosexual and Homosexual Men" in Science (Vol. 253, pp. 1034-1037) stated:

"The discovery that the nucleus differs in size between heterosexual and homosexual men illustrates that sexual orientation in humans is amenable to study at the biological level, and this discovery opens the door to studies of neurotransmitters or receptors that might be involved in regulating this aspect of personality. Further interpretation of the results of this study must be considered speculative."
6/91 Simon LeVay

Related Links: "Are there physical differences in the brain structure of heterosexual and homosexual people?"
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